Antibodies- (Immunoglobulins) "Immunology

قناة متخصصه لشرح مادة الميكروبيولوجي والمناعة لجميع طلبة الكليات العملية In this video we explain the following Structure of Immunoglobulins The basic immunoglobulin unit (monomer) consists of 4 polypeptide chains Two identical heavy chains and two identical light chains held together by disulphide bonds Both light and heavy chains consist of subunits or domains. Each domain consists of 110 amino acids held together in a single loop by an intra-chain disulphide bond Structural Features of Antibody Variable Regions The variable regions of both the light and heavy chain are responsible for antigen-binding, because the core structural unit of each antibody molecule contains two heavy chains and two light chains, every antibody molecule has at least two antigen-binding sites. Structural Features of Antibody Constant Regions The constant region of the heavy chain is responsible for various biologic functions, e.g., complement activation and binding to cell surface receptors. The complement binding site is in the CH2 domain. Effector Biologic Functions of Immunoglobulins Types of Immunoglobulins and Biologic Functions of each antibody #immunology #immunoglobulins #antibodies #المناعة