First pass Metabolism (part-2) Explained | Pharmacology, First-Pass Effect & Bioavailability.

first pass Metabolism Explained | Pharmacology, First-Pass Effect & Bioavailability. First-Pass Metabolism is an important pharmacological process that can affect the bioavailability and therapeutic effects of orally administered drugs. In this video, we explain First-Pass Metabolism in detail, including its mechanism, the role of the liver, its effects on drug bioavailability, and the difference between First-Pass Metabolism and the First-Pass Effect. Effect on Drug Bioavailability-- First-pass metabolism can reduce the amount of unchanged drug reaching systemic circulation, thereby decreasing its oral bioavailability. However, the extent of this effect varies from drug to drug. First-Pass Effect vs. First-Pass Metabolism-- First-pass metabolism refers specifically to the metabolic breakdown or transformation of a drug before it reaches systemic circulation. The first-pass effect describes the overall impact of presystemic losses on the amount of drug reaching systemic circulation. #First Pass Metabolism #First Pass Effect #Pharmacology #Pharmacokinetics #Bioavailability #Drug Metabolism #Drug Absorption #Pharmacy Student#Medical Science. Drugs That Undergo Significant First-Pass Metabolism Examples include: Nitroglycerin Propranolol Morphine Lidocaine The extent of first-pass metabolism differs among these drugs. How Can the First-Pass Effect Be Bypassed? Certain routes of drug administration, such as sublingual, intravenous, and transdermal administration, can bypass the initial hepatic first-pass effect to varying degrees. Intravenous administration bypasses absorption-related first-pass losses entirely, while sublingual and transdermal administration can avoid the initial hepatic first pass when the drug is absorbed through the appropriate tissues.