Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic

Biotransformation of drugs -part 2 | phase 1 & 2 reactions | Pharmacokinatic Metabolism or biotransformation of drugs or medicines is a pharmacokinetic property of drugs which is the irreversible alteration in the chemical nature of a drug. These reactions may be anabolic and catabolic reactions involving mainly endogenous substances like hormones, steroids, etc. but most of the drugs are also undergo these types of reactions and some functional groups are attached or exposed by drug-metabolizing enzymes. Pharmacology is the study of drugs. Pharmacology mainly subdivided into two main branches pharmacokinetic and pharmacodynamic. Pharmacokinetics is mainly concern with the kinetics of drugs inside the body or simply what the body does to a drug. In contrast, pharmacodynamics is concerned with the effects of drugs on the body or simply what the drug does to our body. So, metabolism is pharmacokinetic property through which various changes takes place in the structure of drug which is done to facilitate its excretion from the body through excretory organs. Drugs metabolic reactions are divided into phase 1 and phase 2 reactions. In phase 1 reactions a functional group is exposed or added to the drug structure while in phase 2 reactions an endogenous substance is covalently attached to the drug molecule. Covered topics: Drug Metabolic reactions Phase 1 reactions Oxidation Hydroxylation N-dealkylation O-dealkylation Deamination N-oxidation S-Oxidation Desulfuration dehydrogenations reduction hydrolysis Phase 1 reactions Glucuronide conjugation Acetylation Methylation Sulfate conjugation Glycine conjugation Glutathione conjugation GENERAL OVERVIEW REFERENCES: Goodman and Gilman The Pharmacological Basis of Therapeutics Eleventh Edition Rang and Dale's Pharmacology, Seventh Edition- H. P. Rang Katzung - Basic and Clinical Pharmacology 12th Edition Lippincott Illustrated Reviews, Pharmacology - Whalen, Karen Sixth edition Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa Essentials of Medical Pharmacology(Jaypee) - K.D. Tripathi Seventh edition A Textbook of Clinical Pharmacology and Therapeutics Fifth edition By: JAMES M RITTER, LIONEL D LEWIS, TIMOTHY GK MANT, ALBERT FERRO Netter's Illustrated Pharmacology, Updated Edition- Robert B. Raffa Links: Also watch: drug biotransformaion part 01    • Biotransformation of drugs -part 1 | metab...   How drugs act    • How drug act? | Mechanism of drug action |...   Receptor and its types    • Receptor - pharmacology | Types of recepto...   How drug-receptor interact    • Drug receptor interaction | Pharmacodynami...   Support us on: Facebook https://web.facebook.com/MK-MediGuide... Twitter   / maazkha55086767   #MKmediguideLectures #DrugMetabolism #DrugsBiotransformation #Phase1metabolism #Phase2metabolism #oxidationreactions #reductionreactions #glucuronideconjugation #acetylation #methylation #WhatIsMetabolism #WhatisBiotransformation