Stryer Ch 3 Part 5: Immune System Binding Proteins | TLRs, Antibodies, MHC, T Cells

Stryer Biochemistry, Chapter 3: Binding and Molecular Recognition. Part 5: The immune system depends on key binding proteins. Every section, figure, self-check question and problem is explained, first at the book level and then in simple words, with 3D illustrations and binding curves drawn live. TIMESTAMPS: 0:00 Introduction 0:24 Self and non-self 1:37 Toll-like receptors 2:51 Figure 3.35: the LRR domain 3:26 PAMPs: signatures of pathogens 4:35 Figure 3.36: TLR3 grabs RNA 5:24 Innate vs adaptive 6:16 Figure 3.37: hypervariable regions 7:24 Figure 3.38: the immunoglobulin fold 8:13 Figure 3.39: the Y-shaped IgG 8:53 Figure 3.40: papain cuts IgG 9:37 Figure 3.41: the binding surface 9:58 Figure 3.42: an antibody grips lysozyme 11:14 Self-check: how many loops? 11:53 Figure 3.43: five classes of antibody 13:13 Recombination: millions of antibodies 13:59 Vaccines 14:54 MHC: cut and display 15:46 Figures 3.45 and 3.46: the groove 16:42 Figure 3.47: anchor residues 17:29 Figure 3.48: the T-cell receptor 18:18 Tolerance: not attacking yourself 19:01 Key points 3.4 Source: Stryer, Biochemistry (10th edition), Chapter 3. Book figures shown for educational commentary. #biochemistry #stryer #hemoglobin