Parag answers questions about the Nautilus Proteome Analysis Platform

Nautilus Co-Founder and Chief Scientist Parag Mallick answers questions about the Nautilus Proteome Analysis Platform submitted by the Translating Proteomics community. Parag covers: -How the platform works (our Iterative Mapping methodology for proteome and proteoform analysis) -How we design and characterize probes used in Iterative Mapping -How our limits of detection and quantitation compare to other technologies -How researchers can currently access the Nautilus Platform Chapters 00:00 - Introduction 00:23 - How does Nautilus design and characterize its probes? 14:12 - How do the LOD and LOQ of the Nautilus Platform compare to other technologies? 19:14 - How can researchers currently access the Nautilus Proteome Analysis Platform? Resources Large-scale single-molecule analysis of tau proteoforms https://doi.org/10.1101/2025.06.26.66... A theoretical framework for proteome-scale single-molecule protein identification using multi-affinity protein binding reagents https://doi.org/10.1101/2025.06.26.66...