Demystifying Paroxysmal Nocturnal Hemoglobinuria (PNH) | MedLive by Dr. Priyanka Sachdev

Complete lecture on Paroxysmal Nocturnal Hemoglobinuria (PNH) by Dr. Priyanka Sachdev. In this session, we decode this rare acquired hemolytic anemia: Pathogenesis: The mutation of the PIG-A Gene (GPI Anchor) leading to the absence of protective guards CD55 (DAF) and CD59 (MIRL) on RBCs. Mechanism: Why complement activation during sleep (respiratory acidosis) causes Intravascular Hemolysis. Clinical Features: The Classic Triad of Hemolysis, Pancytopenia, and Thrombosis. Topics Covered include the reason for "Morning Red Urine," the screening Ham's Test (Acidified Serum Lysis), and the confirmatory Flow Cytometry (Bimodal Distribution). Connect with Dr. Priyanka: Instagram:   / medlivebydrpriyanka   Linktree: https://linktr.ee/dr.priyankas Don't miss this opportunity to enhance your knowledge of PNH—subscribe, share, and stay informed!