In Situ, Invasive & Metastatic Cancer Explained | ODS-C

What is the difference between in situ, invasive, and metastatic cancer? This Cells2Cancer lesson uses tissue diagrams, real bladder micrographs, and a fictional colon-to-liver case to explain the words before a code lookup. For more practice with in situ, invasive, and metastatic terminology, see the Registry Foundations section of my Cancer Registry Structure and Management flashcards: https://cells2cancer.com/collection/c.... I explore the basement membrane, why invasion can occur before a bladder tumor reaches muscle, and why the place biopsied may differ from the primary site. I also practice preserving qualifiers and distinguishing regional lymph-node spread from distant disease. No medical background is needed. This is a student led channel. If you spot a correction, comment with a source so we can check it and learn together. Subscribe to Cells2Cancer for more visual study lessons. The chart case is fictional; the teaching images are independent examples. Use the reference editions required for your exam year and the rules that apply to the case. Website: https://cells2cancer.com References Links also appear in slide footers. Public source-page screenshots are from the National Cancer Institute and SEER; relevant text is highlighted for teaching. NCI Dictionary: primary tumor https://www.cancer.gov/publications/d... NCI Dictionary: carcinoma in situ https://www.cancer.gov/publications/d... NCI Dictionary: invasive cancer https://www.cancer.gov/publications/d... NCI Dictionary: adenocarcinoma https://www.cancer.gov/publications/d... NCI Dictionary: lymphatic system; lymph node https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... NCI: Metastatic Cancer; What Is Liver Cancer?; Pathology Reports https://www.cancer.gov/types/metastat... https://www.cancer.gov/types/liver/wh... https://www.cancer.gov/about-cancer/d... SEER Training: Cancer Terms; Bladder Wall Pathology; Bladder Behavior https://training.seer.cancer.gov/dise... https://training.seer.cancer.gov/blad... https://training.seer.cancer.gov/blad... SEER Training: Localized; Regional Spread; Pathology Reports; Casefinding Introduction https://training.seer.cancer.gov/ss2k... https://training.seer.cancer.gov/ss2k... https://training.seer.cancer.gov/case... https://training.seer.cancer.gov/case... Image Credits Cancer Research UK / Wikimedia Commons, CC BY-SA 4.0: bladder layers (CRUK 304), primary and secondary cancer (CRUK 074), and capillary crossing (CRUK 126). Diagrams resized for display; original labels retained. CRUK 126's visible label shows a cell leaving the vessel, despite the file title. https://commons.wikimedia.org/wiki/Fi... https://commons.wikimedia.org/wiki/Fi... https://commons.wikimedia.org/wiki/Fi... License: https://creativecommons.org/licenses/... CoRus13: Urothelial carcinoma in situ, high magnification. CC0. Resized for display. https://commons.wikimedia.org/wiki/Fi... https://creativecommons.org/publicdom... Nephron: Muscle invasive urothelial carcinoma, intermediate magnification. CC BY-SA 3.0. Resized for display. https://commons.wikimedia.org/wiki/Fi... https://creativecommons.org/licenses/... In situ and invasive cancer illustrations: Servier Medical Art, licensed under CC BY 4.0. Resized for display without changing the artwork. https://smart.servier.com/smart_image... https://smart.servier.com/smart_image... License: https://creativecommons.org/licenses/... Branding, presenter artwork, and fictional teaching record: Cells2Cancer. #ODSC #CancerRegistry #CancerEducation