Metaplasia, Dysplasia & Neoplasia: What the Report Says | ODS-C

Untangle metaplasia, dysplasia, neoplasia, and atypia with real tissue images and fictional pathology reports. We compare cell type, abnormal cell appearance, and new growth; show why dysplasia and neoplasia can overlap; and distinguish a benign adenoma from invasive adenocarcinoma. No medical background is needed. Guided NCI and SEER reference lookups connect the vocabulary to cancer-registry work. We practice keeping the specimen location, full diagnosis, and qualifiers such as negative for together. I'm a student in the middle of my ODS-C journey. If you spot a correction, comment with a source so we can check it and learn together. Subscribe to Cells2Cancer for more visual study lessons. CONTENT NOTE: Real microscopic tissue images and discussion of cancer. Watch at your own comfort level. Reports are fictional; source images are independent teaching specimens, not those patients or a progression timeline. Formal registry decisions require the full record and applicable instructions. Use the reference editions required for your exam year. REFERENCES Checked September 16, 2026; linked references also appear in slide footers. NCI Dictionary: metaplasia; dysplasia; neoplasm; atypia https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... NCI Dictionary: adenoma; adenocarcinoma; carcinoma; invasive cancer https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... https://www.cancer.gov/publications/d... NCI: Pathology Reports https://www.cancer.gov/about-cancer/d... NIDDK: Barrett's Esophagus, Definition & Facts https://www.niddk.nih.gov/health-info... MyPathologyReport: Tubular Adenoma; Reactive Changes https://www.mypathologyreport.ca/diag... https://www.mypathologyreport.ca/path... SEER Training: Cancer Terms; Pathology Reports; Casefinding Introduction https://training.seer.cancer.gov/dise... https://training.seer.cancer.gov/case... https://training.seer.cancer.gov/case... IMAGE CREDITS Nephron: Barretts alcian blue. CC BY-SA 3.0. Wider view and right-side crop. Cropped image presentation offered under the same license. https://commons.wikimedia.org/wiki/Fi... https://creativecommons.org/licenses/... AFIP Atlas of Tumor Pathology, via PEIR / Wikimedia Commons: Barrett's mucosa, higher magnification, Alcian blue stain. Public domain. https://commons.wikimedia.org/wiki/Fi... CoRus13: Tubular adenoma, colon, intermediate magnification; Colon adenocarcinoma, biopsy, high magnification. CC BY-SA 4.0. Resized/cropped for display; image adaptations offered under the same license. https://commons.wikimedia.org/wiki/Fi... https://commons.wikimedia.org/wiki/Fi... https://creativecommons.org/licenses/... Mikael Häggström, M.D.: Histopathology of Barrett's esophagus, annotated. CC0. Cropped to focus on tissue; upper source labels omitted. https://commons.wikimedia.org/wiki/Fi... https://creativecommons.org/publicdom... NCI neoplasm and SEER pathology-report webpage screenshots: definition/review paragraphs outlined for guided lookups. Source links above. Branding, presenter artwork, and fictional teaching reports: Cells2Cancer. #ODSC #CancerRegistry #CancerEducation