Myeloid Cells Frontier Forums丨The Role of CD177 for the Function of Human Neutrophil Granulocytes

Introduction CD177 is considered the human analog of murine Ly6G. It´s function is associated with but not limited to trans endothelial migration. The majority of humans does express the molecule, but a sizeable fraction of the population (e.g., ~5% of individuals in Germany) is CD177-deficient without obvious associated health issues. Also, in humans principally expressing the molecule only a fraction of circulating neutrophils is actually CD177+. It has been hypothesized, that initially CD177- neutrophils will ultimately become CD177+ after activation and that both, CD177+ and CD177- cells, are functionally identical. We have investigated this hypothesis in detail and can demonstrate, that the assumptions are wrong. First, CD177+ and CD177- neutrophils are molecularly and functionally very different and second, CD177- cells form a stable neutrophil population in humans, that never expresses the molecule. In my talk I will showcase the evidence supporting our fundings and how this relates to the outcome of human disease. 🔗For more information and the free discussion, visit: https://www.sciexplor.com/webinars/mc/52