JC#20.1 Bone repair: Shh signaling promotes glia-to-mesenchyme transition *** Yutao Zhou

🔎📰 Paper: Shen, X., Zhang, H., Song, Z. et al. . Bone Res 13, 16 (2025). https://doi.org/10.1038/s41413-024-00... Abstract: Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing, and the abnormal plasticity of SCs would jeopardize the bone regeneration. However, how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood. Here, by employing single-cell transcriptional profiling combined with lineage-specific tracing models, we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury. Importantly, our data demonstrated that the Sonic hedgehog (Shh) signaling was responsible for the transition process initiation, which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers. Collectively, these findings depict an injury-specific niche signal-mediated Plp1-lineage cells transition towards Gli1+ MSCs and may be instructive for approaches to promote bone regeneration during aging or other bone diseases. 🌐JC @SJTU: This video belongs to the hybrid Journal Club Program of SJTU, which aims to create international collaborations between labs to enhance students' presentation skills and foster critical thinking. Bilibili version of this video can be found here: https://www.bilibili.com/video/BV1toH... ivLab @ ZhangLab @ Shanghai Jiao Tong University ZhangLab is led by Prof. Zhang Wenjie Department of Prosthodontics Shanghai Ninth People's Hospital School of Stomatology Shanghai Jiao Tong University 115 Jinzhun Road Shanghai China http://vinnikov.science https://x.com/vinnikovLAB