India's Favourite Vasopressor: A Comprehensive Clinical Review of Mephentermine | Dr. Madhuri Patil

#Mephentermine #Vasopressor #ObstetricAnaesthesia #DrMadhuriPatil Mephentermine — marketed as Termine — is a sympathomimetic amine that has quietly become one of the most widely used vasopressors in Indian anaesthesia practice, despite being largely discontinued in Western countries. Structurally related to methamphetamine, it acts predominantly as an indirect sympathomimetic, stimulating the release of norepinephrine from sympathetic nerve terminals to produce mixed alpha- and beta-adrenergic effects — increasing cardiac contractility and heart rate through beta-1 stimulation while causing peripheral vasoconstriction through alpha activity, and uniquely dilating coronary, cerebral, splanchnic, and renal vascular beds even as it raises systemic blood pressure. Its onset of action is immediate with intravenous administration and 5–15 minutes with intramuscular injection, with a duration of roughly 30 minutes intravenously and up to 4 hours intramuscularly — making it a versatile agent for both prophylaxis and treatment of hypotension following spinal and general anaesthesia. Multiple randomised trials comparing mephentermine with ephedrine and phenylephrine for spinal anaesthesia-induced hypotension in caesarean section have consistently shown comparable efficacy in maintaining maternal blood pressure with similar neonatal outcomes on Apgar scores and umbilical cord blood gas analysis, though ephedrine may achieve a slightly faster and more sustained pressor response while mephentermine has been found to be considerably more potent on a milligram-for-milligram basis. In this comprehensive clinical review, Dr. Madhuri Patil takes anaesthesiologists through the complete pharmacological profile of mephentermine — from its mechanism of action to its clinical applications, comparative evidence, dosing, and safety considerations — making this an essential refresher for a drug used in operating theatres across India every single day. This session is essential for anaesthesiologists, obstetric anaesthesia practitioners, residents, and all clinicians who routinely use vasopressors to manage perioperative hypotension. About Ozone Learning Academy: Ozone Learning Academy is the academic initiative of the Ozone Anaesthesia Group, offering weekly Thursday evening sessions on clinically relevant anaesthesia and perioperative topics by expert faculty, for continuous professional development. 📌 Don't forget to: 👍 Like this video if it refreshed your understanding of this everyday drug 🔄 Share it with your anaesthesia colleagues, residents, and obstetric anaesthesia teams 🔔 Subscribe to Ozone Learning Academy and hit the bell icon for every Thursday academic session 📺 Subscribe now: \[    / @ozoneanaesthesiagroup  ] 💬 Comment below — Is mephentermine your go-to vasopressor for spinal hypotension? Share your practice! #Mephentermine pharmacology #Mephentermine anaesthesia #Vasopressor spinal hypotension #Mephentermine vs ephedrine #Mephentermine mechanism of action #Spinal anaesthesia hypotension #Dr Madhuri Patil #Ozone Learning Academy #Ozone Anaesthesia Group #Obstetric anaesthesia vasopressor #Mephentermine dosing #Sympathomimetic drugs anaesthesia #Caesarean section hypotension #Mephentermine clinical review #Anaesthesia pharmacology 🌐 Ozone Learning Academy - Where Expertise Meets Excellence ##in Anesthesiology. Credits Video Editing- Vipul Tribhuwan/Dr. Sujitkumar Khade Concept & Thumbnail - Dr. Sujitkumar Khade Production- Ozone Anaesthesia Group