FREE RADICAL MEDIATED CELL INJURY

A series of video tutorials discussing the pathology of cell injury and adaptations. In this tutorial , i have discussed PATHOGENESIS of free radical mediated Cell injury ***Follow me**** http://ilovepathology.com/ Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   FREE RADICAL MEDIATED CELL INJURY • These are the chemical species/ atoms or group of atoms that have single or more unpaired electrons in their outer orbit. • Highly reactive, unstable chemicals Conditions where free radicals are implicated in cell injury and death • Injury due to chemicals/drugs • Ischemia reperfusion injury • Irradiation • Phagocytosis leading to killing of microbes • Cellular aging • Carcinogenesis Free radicals • Superoxide oxygen • Peroxide (Hydrogen peroxide) • Hydroxyl radical • Nitric oxide • Peroxynitrite • Hypochlorous acid Antioxidant mechanisms Enzymatic Antioxidants • Catalase • Superoxide dismutase • Glutathione peroxidase Non-enzymatic Antioxidants • Endogenous or exogenous substances which inactivate free radicals • Vitamins A, C , E • Sulphydryl containing compounds • Cysteine and glutathione • Serum proteins • Ceruloplasmin and transferrin ~-~~-~~~-~~-~ Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"    • NEOPLASIA 6: WARBURG EFFECT: Hallmark of  ...   ~-~~-~~~-~~-~