First pass Metabolism (part-1) |Metabolism|pharmacology|what is first pass Metabolism.

First-pass Metabolism explained|Pharmacology,first pass effect & bioavailability. First-Pass Metabolism is an important pharmacological process that can affect the bioavailability and therapeutic effects of orally administered drugs. In this video, we explain First-Pass Metabolism in detail, including its mechanism, the role of the liver, its effects on drug bioavailability, and the difference between First-Pass Metabolism and the First-Pass Effect. First-pass metabolism, first-pass metabolism explained, first-pass effect, hepatic first-pass metabolism, pharmacology for beginners, drug bioavailability, oral drug administration, liver metabolism, pharmacokinetics, drug absorption, routes of drug administration, pharmacy education. #FirstPassMetabolism #FirstPassEffect #Pharmacology #Pharmacokinetics #Bioavailability #DrugMetabolism #DrugAbsorption #PharmacyStudents #MedicalScience. Topics Covered in This Video 1. What Is First-Pass Metabolism? First-Pass Metabolism is the metabolism of a drug before it reaches the systemic circulation, mainly during its passage through the intestinal wall and liver after oral administration. 2. Mechanism of First-Pass Metabolism After an oral drug is swallowed, it generally follows this pathway: Oral Drug Administration--- Gastrointestinal Absorption-- Portal Venous Circulation-- Liver Metabolism-- Systemic Circulation. During this process, some of the absorbed drug may be metabolized before reaching the general bloodstream. 3. Role of the Liver in Drug Metabolism The liver contains drug-metabolizing enzymes, including Cytochrome P450 enzymes, that can transform drugs into metabolites. Depending on the drug, these metabolites may be inactive, active, or potentially toxic. 4. Effect on Drug Bioavailability First-pass metabolism can reduce the amount of unchanged drug reaching systemic circulation, thereby decreasing its oral bioavailability. However, the extent of this effect varies from drug to drug.