3. How Innate Immune System Works? PAMPs, TLRs & Chemokines

Your immune system has no eyes. It cannot see a bacterium. So how does it know an infection has started? The answer is a chain with four links — inducer, sensor, mediator, target — and once you can see that chain, most of innate immunity falls into place. Episode 3 follows it from a single molecule of bacterial lipopolysaccharide all the way to the redness and swelling you can see with your own eyes. Chapters: 00:00 Your immune system has no eyes 00:34 Link 1: inflammatory inducers 00:52 Danger signals from your own damaged tissue 01:12 Link 2: sensor cells and pattern-recognition receptors 01:37 Patterns, not species — the PAMPs 02:14 Reading the surface of a macrophage 02:26 Toll-like receptors: TLR-1/2 and TLR-4 02:45 NOD-like receptors and sensing from inside the cell 03:11 Link 3: cytokines and chemokines 03:37 Link 4: calor, dolor, rubor, tumor 03:52 What actually causes each of the four signs 04:23 Who arrives, and in what order 04:35 Lymph, and the handover to adaptive immunity Built from Janeway's Immunobiology, for medical students, residents and anyone revising immunology from the ground up. More from Rheumatology Digest: Website: https://rheumatologydigest.org WhatsApp channel: https://whatsapp.com/channel/0029Vb6P... #immunology #innateimmunity #pamps #tollikereceptors #inflammation #medicalstudent #usmle #neetpg