The 20-Year Game Of Protecting A Drug | Techie Lawyer | Prayank Khandelwal ft. Nicole Mastrangelo

https://photonlegal.com ------------- Nicole Mastrangelo nearly became a doctor. She studied gene editing for ALS and SMA at Biogen and Huntington's disease at Mass General before a professor pointed her toward the law — and she became a patent attorney who now protects the very innovations she once built. In this episode, Prayank Khandelwal and Nicole Mastrangelo get into her scientist-to-IP-counsel journey, the shift from doing the work to setting the strategy, how she convinces a CFO to fund multi-jurisdiction filings, why one patent is never enough — you build a thicket that protects a drug across its 20-year term and beyond — and how she uses AI on a strict "trust but verify" model. "You don't just file one patent and wait twenty years. You build a thicket — a child, a grandchild, a great-grandchild — so the product is never left at risk." — Nicole Mastrangelo If you're a patent attorney, a founder, or a scientist trying to protect what you build, this one's for you. Subscribe for more such podcasts. ------------- Meet the panel: The Host: Prayank Khandelwal   / prayankkhandelwal   The Guest: Nicole Mastrangelo, IP Counsel, Broad Institute of MIT and Harvard   / nicole-mastrangelo-26201729   ------------- TIMESTAMPS 00:00 Introduction 01:31 Welcome to the show 01:57 From near-doctor to patent attorney: her journey 04:17 Doer to strategist: moving in-house 06:34 The first things she does as an in-house IP counsel 08:20 Her non-negotiables when reviewing patents 10:11 Enabling the business to make IP-driven decisions 11:20 Convincing the CFO to fund multi-jurisdiction filings 12:33 Tiering jurisdictions: where and why to file 14:30 Expedite or wait? Why she never fast-tracks 17:00 Why one patent isn't enough: building the thicket 21:00 Extending protection across the 20-year term 23:00 Teaching IP & technology at law school 25:00 Using AI on a "trust but verify" model 27:00 Would she trust AI with patent translation? 27:45 The biggest cost driver in global filings 28:40 The toughest patent office: China ------------- Disclaimer: This podcast is produced for in-house counsel, GCs, law students, aspirants and the wider legal community. The views shared are personal to the hosts and guests and do not represent their employers, firms, or clients. The discussion is for informational purposes only, does not constitute legal advice, and does not create an attorney–client relationship with Photon Legal or any participant. This episode is not an advertisement or solicitation for legal services in India, the United States, or any other jurisdiction.