The Pharmacology Every USMLE Step 1 Question Is Built On | Day 3 of 56

Day 3 of 56 Days to Pass USMLE Step 1: General Pharmacology in 16 minutes. Pharmacokinetics (bioavailability, volume of distribution, half-life and steady state, zero vs first order, loading and maintenance doses, CYP450 inducers and inhibitors), pharmacodynamics (potency vs efficacy, agonists, partial agonists and antagonists, therapeutic index, G-proteins and receptors) and autonomic drugs (cholinergic and anticholinergic toxidromes, organophosphate poisoning, pressors, epinephrine reversal, beta-blockers). Real images, motion diagrams and 3 NBME-style practice questions. Hey, colleagues! I'm Dr. Aryan. Every day for 56 days we cover one block of Step 1, only what NBME and USMLE actually test. Subscribe and study with me. ▶ Free 50-question sample exam (no card): https://steplobe.com/yt/day03 ▶ The 56-day plan and my Step 1 books: https://steplobe.com/books ▶ Pass guarantee terms: https://steplobe.com/guarantee ▶ Day 2 (amyloid, cancer genes, clots and shock):    • The Pathology Every USMLE Step 1 Question ...   CHAPTERS 0:00 Same pill, same dose: why one bleeds, one clots 0:22 Welcome: Day 3 plan 0:55 Pharmacokinetics 0:58 Bioavailability 1:20 Volume of distribution 1:52 Half-life and steady state 2:21 Zero vs first order kinetics 2:47 Loading vs maintenance dose 3:08 Phase I vs phase II metabolism 3:35 CYP450 inducers and inhibitors 4:09 Grapefruit juice (real image) 4:17 Practice question 1: the pill that failed 5:11 Summary: pharmacokinetics in 5 points 6:05 Pharmacodynamics 6:15 Potency vs efficacy: dose-response curves 6:35 Agonists, partial agonists and antagonists 7:07 Therapeutic index 7:32 G-proteins: Gs, Gi, Gq 8:03 Receptor families 8:30 Practice question 2: buprenorphine withdrawal 9:30 Summary: pharmacodynamics in 5 points 10:05 Autonomic pharmacology 10:17 Sympathetic vs parasympathetic wiring 10:48 Receptors: alpha, beta, M, N 11:16 Cholinergic drugs 11:46 Organophosphate poisoning: atropine + pralidoxime 12:20 Pinpoint pupils (real image) 12:26 Anticholinergic toxidrome: hot, dry, red, blind, mad 12:57 Jimsonweed (real image) 13:04 Pressors 13:31 Epinephrine reversal 13:49 Beta-blockers 14:19 Practice question 3: poisoned or sympathomimetic? 15:10 Summary: autonomic drugs in 5 points Image credits (Wikimedia Commons) "Grapefruit cut" by Jedesto, CC BY-SA 4.0 "Human eye in bright light" by Rapidreflex, CC BY-SA 4.0 "Datura stramonium 722884013" by Alex Abair, CC BY 4.0 "Hypericum perforatum, Castle Shannon" by Cbaile19, CC0 "Adrenal paraganglioma clinical Pheochromocytoma" by Michael Feldman, MD, PhD, CC BY 2.0 Thumbnail photo: "Citrus paradisi (Grapefruit, pink) white bg" by Citrus_paradisi_(Grapefruit,_pink).jpg: א (Aleph) derivative work: — raeky, CC BY-SA 2.5, https://creativecommons.org/licenses/..., https://commons.wikimedia.org/wiki/Fi..., cropped and labelled. For education only, not medical advice. USMLE is a joint program of the FSMB and NBME; StepLobe is not affiliated with them. #USMLE #USMLEStep1 #Pharmacology