Cellular & Molecular Biology of the KIDNEY | Nephrology Series from Harrison | by Dr Sudhir

In this session, let us breaks down the essential Cellular and Molecular Biology of the Kidney, covering high-yield concepts straight from Harrison’s Principles of Internal Medicine (22nd Edition). Understanding renal molecular mechanics and cellular architecture is key to mastering nephrology. We have tried to keep it as simple and clinically essential as possible. [00:00] — Introduction & Clinical Correlation Approach [01:02] — Cortical vs. Juxtamedullary Nephrons (Anatomy & Functional Differences) [02:43] — Glomerular Biology & GFR Autoregulation [06:44] — Clinical Correlation: Glomerulus [08:27] — Proximal Convoluted Tubule (PCT) [14:07] — Clinical Correlation: PCT (Fanconi Syndrome, CKD Mineral Bone Disease) [15:15] — Loop of Henle (Countercurrent Multiplier System) [18:00] — Clinical Correlation: Loop of Henle [19:13] — Distal Convoluted Tubule (DCT) [20:22] — Clinical Correlation: DCT [23:01] — Collecting Tubule & Duct System [23:26] Principal Cells & Aldosterone [26:26] Pharmacology: Potassium-Sparing Diuretics [28:08] Intercalated Cells: Type A Intercalated Cells Type B Intercalated Cells (Pendrin Transporter) [30:08] — Antidiuretic Hormone (ADH) & Urea Recycling [32:27] — Renin-Angiotensin-Aldosterone System (RAAS) Activation [35:41] — Aldosterone Escape Mechanism [37:56] — Summary & Key Takeaways #InternalMedicine #Nephrology #HarrisonsNephrology #DrSudhir #MedicalEducation #NephronBiology If you found this video helpful: Like the video to support the series Subscribe to the channel for regular internal medicine deep dives Comment below with your questions or topics you'd like covered next!