Class (45.2) Action Potential = Depolarization + Repolarization + Hyperpolarization | Medichem 01

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... Solution Pharmacy will cover this syllabus of medicinal chemistry 01 for B.Pharmacy 4th semester Unit 04 – (01) Drug acting on the central nervous system – (02) Sedative and hypnotics – Benzodiazepine – SAR of benzodiazepine, Chlordiazepoxide, Diazepam, Oxazepam, clorazepate, lorazepam, alprazolam, zolpidem (03) Barbiturate – SAR of barbiturate- Barbital, phenobarbital, Mephobarbital, amobarbital, butobarbitals, Pentobarbital, secobarbital (04) Miscellaneous – Amides and Imides – Glutethimide, alcohol and their carbamate derivatives- meprobamate, Ethchlorvynol (05) Antipsychotic - Phenothiazine – SAR of phenothiazine, promazine hydrochloride, Chlorpromazine hydrochloride. (06) Ring analogous to phenothiazine (07) Fluoro butyrophenone – Haloperidol, droperidol, risperidone (08) Beta amino ketone – Molindone hydrochloride (09) Benzamides – sulpieride (10) Anticonvulsant – SAR of anticonvulsant, mechanism of action of anticonvulsant (11) Barbiturate – phenobarbital, metharbital (12) Hydantoin – Phenytoin, mephenytoin, etozolin (13) Oxazolidine Dione – Trimethadione, paramethadione (14) Succinimide-Phensuximide, Methsuximide, Ethosuximide, (15) Urea and monoacylurase – Phenacemide, carbamazepine (16) Benzodiazepine – clonazepam Action Potential = Action potential means the potency of ions to initiate the action in the form of a nerve impulse. Action Potential Consists of following steps- 1- Resting Membrane Potential 2- Depolarization 3- Rise in Depolarization 4- Repolarization 5- Hyper Polarization When positive ions enter the cell, it causes an increase in the membrane potential of the cell. The membrane potential increases until the threshold potential is reached. The voltage-gated sodium channels open and allow sodium to come rushing into the neuron at the junction of the axon and cell body. At this point, the cell undergoes depolarization, which is a rapid increase in membrane potential. This response is all or none, meaning that once the depolarization starts, it goes on for a set amount of time, then the sodium channels slam shut, preventing the axon from depolarizing. After the action potential is sent down the axon, the initial segment needs to be reset to start a new impulse. This phase is called repolarization. When the membrane potential increases to a certain level, voltage-gated potassium channels open. Potassium also has a positive charge, but when the channel open, potassium rushes out of the cell. Since the positive ion s leaving the cell it makes the cell more negative. E-Mail for official and other work - solutionpharmacy@gmail.com #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT