Extrinsic & Intrinsic Apoptosis & Autophagy | Developmental Biology | CSIR DBT JRF 2026 | IFAS

Extrinsic & Intrinsic Apoptosis & Autophagy explained with clear concepts and exam-focused approach. Master apoptosis pathway, autophagy mechanisms, and C. elegans programmed cell death for CSIR DBT JRF 2026. This session covers PYQs, mutation analysis tricks, and problem-solving strategies. 🔥 Join India's Best Life Science Coaching - IFAS Online! 🔥 Exclusive Crash Live Course Batch: Starts on 01 June 2026 🔥 Live Online Batch: Super Emotion Batch 7.6 - Starts on 18 May 2026 🔥 Recorded Online Batch: Revolution Batch 7.6 from Live Batch Completed on 25 April 2026 📞 Need Guidance? Call/WhatsApp: 9172266888 ━━━━━━━━━━━━━━━━━━━━━━━━━ ⏳ Lecture Timeline: [00:00:00] – Introduction to Apoptosis Pathways [00:08:50] – Caspases: Cysteine-Asp Proteases [00:10:10] – Zymogens: Inactive Precursors [00:10:48] – Initiator & Effector Caspases [00:12:06] – Caspase Targets: ICAD, Lamins, Cytoskeleton [00:15:18] – PS Flipping: Eat-Me Signal [00:16:38] – PARP-1 Cleavage: Apoptosis Marker [00:17:40] – Apoptotic Caspases (2,8,9,10,3,6,7) [00:19:51] – Important: Not All Caspases Apoptotic [00:21:25] – C. elegans Model: 131 Cells Die [00:23:19] – CED-4 & CED-3: Adapter & Effector [00:24:09] – Mutation: Gain/Loss Function Logic [00:26:25] – CED-9: Anti-Apoptotic (Bcl-2 Homolog) [00:33:55] – EGL-1: Pro-Apoptotic BH3-Only [00:38:44] – Conservation: Mammalian Homologs [00:48:50] – Highly Conserved Apoptosis Proteins [00:54:41] – CED-9 Resides on Mitochondria [00:55:49] – CED-4 Sequestration by CED-9 [00:57:33] – CED-3: Executioner Caspase [01:00:25] – Question: CED-4 LOF, CED-3 Normal [01:14:48] – Additional Proteins: CED-8, CED-5, CED-6 [01:15:16] – CED-8: PS Flippase [01:17:44] – CED-5: Rac GEF for Engulfment [01:19:56] – CED-6: PTB Adapter in Engulfment [01:21:35] – Mammalian Pathway Preview: Bcl-2 to Casp-3 [01:24:04] – Practice Questions Assigned [01:30:20] – Complete Session: Apoptosis & C. elegans ━━━━━━━━━━━━━━━━━━━━━━━━━ 📖 Topics Covered in This Lecture: • Caspases initiator effector roles • C. elegans Ced-9 Ced-4 Ced-3 pathway • BH3-only, Bcl-2, Apaf-1 conserved proteins • Engulfment proteins Ced-5 Ced-8 • Extrinsic vs intrinsic apoptosis overview • Autophagy regulation basics • PYQ mutation analysis tricks ━━━━━━━━━━━━━━━━━━━━━━━━━ 📚 Lecture Summary: In this session, IFAS Expert Faculty focuses on extrinsic and intrinsic apoptosis pathways and autophagy, detailing C. elegans programmed cell death with Egl-1, Ced-9, Ced-4, Ced-3. Initiator and effector caspases, conserved Bcl-2 and Apaf-1 proteins, and engulfment genes are explained. Gain-of-function and loss-of-function mutation strategies are applied to PYQs, solidifying apoptosis concepts for CSIR DBT JRF. ━━━━━━━━━━━━━━━━━━━━━━━━━ 🎓 This lecture is highly beneficial for students preparing for: ✅ CSIR NET Life Science ✅ GATE Life Science ✅ GATE Biotechnology ✅ GATE Ecology & Evolutuon ✅ BET (DBT) ✅DHR ICMR (BRET) ✅ TIFR Biology  ✅ BARC Bioscience  ✅ SET / PhD Entrance Exams ━━━━━━━━━━━━━━━━━━━━━━━━━ 🏆 Why IFAS is India’s No. 1 Choice for CSIR NET & GATE Life Science? (Our Results Speak): ✅ CSIR NET Dec 2025: 4000+ Selections (AIR 3, 8, 9, 9...) ✅ CSIR NET June 2025: 4200+ Selections (AIR 1, 2, 6, 10...) ✅ CSIR NET Dec 2024: 4000+ Selections (AIR 5, 6, 7, 8, 9...) ✅ CSIR NET June 2024: 2000+ Selections (AIR 3, 10, 13...) ✅ CSIR NET Dec 2023: 1200+ Selections (AIR 2, 4, 5...) 📄 View IFAS Result Sheet: 👉 https://drive.google.com/file/d/1THh6... ━━━━━━━━━━━━━━━━━━━━━━━━━ 🔗 Important Links: 🌍 Visit our Website: https://ifasonline.com 📞 Contact for Queries: 9172266888 📘 Free Counselling: https://ifasonline.com/csir-net/life-... ━━━━━━━━━━━━━━━━━━━━━━━━━ 🔗 India's Best Online Classes and Books: 🔥CSIR NET Life Science Live & Recorded Course: https://ifasonline.com/csir-net/life-... 🎯 GATE Life Science Recorded Course: https://ifasonline.com/gate/life-scie... 🎯 GATE Biotechnology Recorded Course: https://ifasonline.com/gate/biotechno... 📘CSIR NET Life Science Books: https://ifasonline.com/csir-net/life-... ━━━━━━━━━━━━━━━━━━━━━━━━━ 📲 Download IFAS App: Android: https://play.google.com/store/apps/de... IOS: https://apps.apple.com/us/app/ifas/id... ━━━━━━━━━━━━━━━━━━━━━━━━━ Stay Updated Via Other Social Media: ✔ Telegram: https://t.me/IfasLifeScience ✔ Instagram:   / csir_net_life_science_ifas   #apoptosissignalingpathway #developmentalbiology #csirnetlifescience #gatelifescience #gatebt #setlifescience