Lysozyme Nephropathy Explained: How It Causes Kidney Injury

What is lysozyme nephropathy, and why can it cause acute or chronic kidney injury? Lysozyme nephropathy is a kidney complication associated with conditions that produce excessive amounts of lysozyme, particularly certain myeloid disorders such as chronic myelomonocytic leukemia (CMML). 🫘 How does lysozyme damage the kidneys? Lysozyme is a small protein that is filtered by the glomerulus and normally reabsorbed by proximal tubule cells. When lysozyme levels become very high: Excess lysozyme → increased tubular uptake → proximal tubular injury → kidney dysfunction This can cause: Acute kidney injury or progressive CKD Proteinuria, often with tubular proteins Electrolyte abnormalities from proximal tubular dysfunction Fanconi syndrome in some patients 🔬 Kidney biopsy may show prominent lysozyme accumulation in proximal tubular cells, and immunostaining can help confirm the diagnosis. 🩺 Treatment The most important step is treating the underlying hematologic disorder and reducing the excessive lysozyme production. Supportive kidney care is also important. Lysozyme nephropathy is a good example of how a protein produced in excess by abnormal blood cells can directly injure the kidney. ⚠️ Medical Disclaimer: This video is for educational purposes only and does not replace individualized medical advice. #LysozymeNephropathy #CMML #KidneyDisease #AcuteKidneyInjury #FanconiSyndrome #ProximalTubule #Nephrology #KidneyHealth #KidneyClarity