Epigenomics: Recording the Past and Predicting the Future

Jason Buenrostro, Ph.D., examines how epigenetic mechanisms regulate gene expression and record environmental influences. The presentation highlights advances in chromatin accessibility profiling, including single-cell ATAC-seq, and shows how these tools enable high-resolution mapping of regulatory elements across cell populations. It also demonstrates how computational and AI-based methods uncover transcription factor interactions and gene regulatory networks. A featured case study explores inflammatory memory, showing how transient signals can produce lasting epigenetic changes that influence disease risk. Video Chapters: 00:00 - Introduction by Yashwanth Ashok 01:13 - Introduction to Epigenetic Regulation 03:45 - Chromatin Accessibility and Single-Cell ATAC-seq 05:09 - Decoding Transcription Factor Interactions with AI 15:40 - Inflammatory Memory and Lasting Epigenetic Changes 22:35 - Implications for Disease and Precision Medicine 24:43 - Q&A with Yashwanth Ashok and Jason Buenrostro Learn more by visiting the Buenrostro Lab https://www.buenrostrolab.com/ #epigenetics #genomics #singlecell #computationalbiology Remember to like, subscribe, and hit the notification bell to stay updated on our latest content! Disclaimer: Genome TDCC does not endorse or recommend any commercial products or services. Inclusion of a speaker's views or opinions on our channel does not constitute endorsement by Genome TDCC, The Jackson Laboratory (JAX), National Human Genome Research Institute (NHGRI), or the U.S. Government. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not constitute or imply its endorsement, recommendation, or favoring to the exclusion of other available products, processes, or services.