Antibiotic Dosing in Kidney Failure, Dialysis, Obesity & Pregnancy | Antibiotics Ep 6

Cutting the first dose because the creatinine is high is one of the commonest prescribing errors. Learn why the loading dose never changes, how to calculate creatinine clearance and adjusted body weight, which weight to use for each drug, augmented renal clearance, which drugs dialysis removes, and how to prescribe in liver disease, obesity, pregnancy and breastfeeding. In this episode: • Loading vs maintenance dose, with worked examples • Cockcroft-Gault, creatinine clearance vs eGFR, and when the formula fails • Ideal and adjusted body weight; which weight for which drug • Augmented renal clearance and the higher doses it needs • Dialysis rules and a one-glance kidney, dialysis and liver table • Pregnancy and breastfeeding: which antibiotics are safe Every mechanism, algorithm and dosing table is drawn step by step on the whiteboard, with exact adult doses, kidney adjustments, mnemonics, worked examples and exam pearls. Built for medical students, house officers and residents preparing for ward work, TOACS/OSCE, long cases and vivas. CHAPTERS 0:00 Introduction 0:17 Special situations: the essentials 0:54 Two doses, two different questions 1:40 Worked example: the same first dose 3:12 Cockcroft-Gault: creatinine clearance 4:02 Worked example: two patients 4:50 Creatinine clearance versus estimated glomerular filtration rate 5:46 When the formula fails 6:28 Ideal and adjusted body weight 7:07 Worked example: a 110 kg man, 175 cm tall 8:10 Algorithm: choosing the aminoglycoside dosing weight 8:48 Which weight for which drug? 9:54 Augmented renal clearance: the kidney that works too well 10:40 Augmented renal clearance: the higher doses 11:18 Which drugs need a kidney adjustment? 12:14 Dialysis: which drugs are removed? 13:11 Dialysis rules 14:14 One-glance kidney, dialysis and liver table (1) 15:34 One-glance kidney, dialysis and liver table (2) 16:51 Severe liver failure 17:27 Obesity, critical illness and extracorporeal support 18:08 Pregnancy: the general rule 18:40 Pregnancy and breastfeeding (1) 19:50 Pregnancy and breastfeeding (2) 21:24 Key points 22:31 Closing ▶ Watch next: Ep 7: Before You Prescribe: Cultures, the Susceptibility Report and Resistance Risk THE SERIES: 32 episodes in 6 modules Module 1: Foundations (Ep 1–8) Module 2: The Drugs, Class by Class (Ep 9–20) Module 3: The Resistant Organisms (Ep 21–24) Module 4: Bug–Drug Atlas (Ep 25–26) Module 5: Empiric Therapy by Syndrome (Ep 27–31) Module 6: Revision (Ep 32) Full playlist: [paste your playlist link here] Subscribe to Marker Medic for complete, exam-ready internal medicine series, explained on the whiteboard. For medical education only. Not a substitute for clinical judgement or your local guidelines; always check drug doses against current local references and your hospital antibiogram. #Antibiotics #Nephrology #ClinicalPharmacology #MedicalEducation #MedicalStudent