Press-Pulse Protocol: Ketogenic Diet for Cancer | Dr. Tomas Duraj (Thomas Seyfried Lab)

KMT Discussion Community and support me on Patreon:   / drtomasduraj   BMC Medicine publication: https://doi.org/10.1186/s12916-024-03... Macronutrient calculator and GKI tracking sheet: https://media.springernature.com/orig... Supplementary information of the BMC Medicine publication, including Appendix and summary tables with dietary supplements and press-pulse interventions: https://link.springer.com/article/10.... Visit our lab faculty website for more research: https://www.bc.edu/bc-web/schools/mor... 00:00 Implementing Ketogenic Metabolic Therapy (KMT) 04:05 Navigating Research Certainty vs. Emerging Evidence 07:46 BMC Medicine Framework for Glioblastoma 10:40 What to Eat (Paleolithic Ketogenic Diet Summary) 14:23 Bioenergetic Premise: Warburg effect & Cancer Metabolism 16:15 Metabolic Inflexibility of Cancer Cells 20:25 Healthy Cells vs. Oxidative Phosphorylation Insufficiency 23:36 Substrate-Level Phosphorylation (Glycolysis & Glutaminolysis) 27:00 Overarching Goal of KMT 30:11 The Press-Pulse Therapeutic Principle 33:00 Nutritional Ketosis vs. Calorie Restriction 36:31 Step 1: Tracking Phase (Weeks 1–2) 40:04 Capillary Blood Glucose & Ketone Meters 42:01 Continuous Glucose (CGM) & Ketone (CKM) Sensors 48:00 Electrolytes & Preventing Keto Flu 50:51 Step 2: Transition Phase (Weeks 3–4) 52:50 Macronutrient Targets (Carb Limits & Protein Intake) 56:52 Proposed Therapeutic Zone & Target GKI (2.0 and 1.0) 59:34 Food Choices, Fiber & Meal Timing 1:03:26 Fat Sources & Caloric Balance 1:07:50 Step 3: Maintenance Phase (Weeks 4–6) 1:09:12 Establishing Fasting & Dietary GKI Baselines 1:10:45 Pharmacological Pulses & Repurposed Glycolysis Inhibitors 1:13:17 Targeting Glutamine (DON, Sodium Phenylbutyrate, Supplements) 1:17:04 Standard of Care, Corticosteroids & Window of Opportunity 1:20:42 Fasting Protocols (Intermittent, Prolonged, Refeeding) 1:28:02 Contraindications & Weight Maintenance 1:29:34 Troubleshooting GKI: Sweeteners & Dawn Phenomenon 1:33:25 Healthy Fat Loss vs. Cancer Cachexia 1:36:54 Exercise Guidelines to Preserve Muscle Mass 1:39:46 Laboratory Testing & Recommended Blood Work 1:43:25 Conclusion & Final Thoughts